Subhas Chandra Roy

Sr. Professor


E-Mail : ocscr at iacs.res.in

Short Bio-data :

Dr. Roy received his B.Sc. with honours in chemistry from Burdwan University and M.Sc. with specialisation in Organic Chemistry from Kalyani University. In 1978 he joined the Department of Organic Chemistry, Indian Association for the Cultivation of Science, Calcutta for doctoral research under the supervision of Professor U.R. Ghatak. Based on his work on synthetic studies in condensed cyclic systems using the chemistry of a-diazocarbonyl compounds he was awarded with Ph.D. degree of Calcutta University in 1983. He did his post-doctoral research with Professor R.G. Salomon of Case Western Reserve University, USA, during the years 1985-1987 and 1997-1998 on synthesis of natural products and their biological evalution. In 1984, he joined the faculty of organic chemistry at IACS as Research Assistant, where he is presently Professor of Organic Chemistry.

Current Research Interest :

Synthesis of bio-active natural products and related compounds mainly involving radical chemistry. Development of novel methodologies and reagents.

Awards and Honours:

Elected Fellow of West Bengal Academy of Science and Technology - 2007
Awarded Chemical Research Society of India Bronze Medal - 2008

Future plans :

Asymmetric synthesis of natural products of biological significance. Development of synthetically important methodologies.

Selected list of important recent publications :

1.  Stereoselective Synthesis of Polysubstituted Tetrahydrofurans by Radical Cyclization of Epoxides using a Transition-Metal Radical Source. Application to the Total Synthesis of (±)-Methylenolactocin and (±)-Protolichesterinic Acid,
Pijus Kumar Mandal, Gourhari Maiti and Subhas Chandra Roy,
J. Org. Chem.,1998, 63, 2829.
2. Short and Stereoselective Total Synthesis of Furano Lignans (±)-Dihydrosesamin, (±)-Lariciresinol dimethyl ether, (±)-Acuminatin methyl ether, (±)-Sanshodiol methyl ether, (±)-Lariciresinol, (±)-Acuminatin, (±)-Lariciresinol monomethyl ether, and Furofuran Lignans (±)-Sesamin, (±)-Eudesmin, (±)-Piperitol methyl ether, (±)-Pinoresinol, (±)-Piperitol, (±)-Pinoresinol monomethyl ether by Radical Cyclization of Epoxides using a Transition-Metal Radical Source,
Subhas Chandra Roy, Kalyan Kumar Rana and Chandrani Guin,
J. Org. Chem., 2002, 67, 3242.
3. Concise enantioselective synthesis of furano lignans (-)-dihydrosesamin and (-)-acuminatin and furofuran lignans (-)-sesamin and (-)-methyl piperitol by radical cyclization of epoxides,
Biplab Banerjee and Subhas Chandra Roy,
Synthesis, 2005, 2913.
4. Radical promoted Wagner-Meerwein-type rearrangement of epoxides in camphoric systems using a Ti(III) radical source’,
Samaresh Jana, Chandrani Guin and Subhas Chandra Roy,
J. Org. Chem., 2005, 70, 8252.
5. Stereoselective synthesis of polysubstituted tetrahydropyrans by radical cyclization of epoxides using a transition-metal radical source,
Biplab Banerjee and Subhas Chandra Roy,
Eur. J. Org. Chem., 2006, 489.
6. Radical promoted cyclizations of aromatic carbonyl compounds to benzopyrans using titanocene(III) chloride,
Samaresh Jana and Subhas Chandra Roy,
Tetrahedron Lett., 2006, 47, 5949.
7. Titanocene(III) chloride mediated radical-induced one pot synthesis of a-methylene-g-butyrolactones,
Moumita Paira, Biplab Banerjee, Samaresh Jana, Samir Kumar Mandal and Subhas Chandra Roy,
Tetrahedron Lett., 2007, 48, 3205.
8. Titanocene(III) Mediated Radical Cyclizations of Epoxides for the Synthesis of Medium-Sized Cyclic Ethers,
Samir Kumar Mandal and Subhas Chandra Roy,
Tetrahedron, 2007, 63, 11341.
9. Titanocene(III) Chloride Mediated Radical-Induced Addition to Baylis-Hillman Adducts: Synthesis of (E)- and (Z)-Trisubstituted Alkenes and a-Methylene/Arylidene-d-Lactones,
Samir K. Mandal, Moumita Paira, and Subhas C. Roy, J. Org. Chem., 2008, 73, 3823-3827.
10. Titanocene(III) Chloride Mediated Radical-Induced Synthesis of 3,4-Dihydroisocoumarins: Synthesis of (±)-Hydrangenol, (±)-Phyllodulcin, (±)-Macrophyllol and (±)-Thunberginol G,
Samir Kumar Mandal, and Subhas Chandra Roy,
Tetrahedron, 2008, 64, 11050 .
11. Titanocene(III) chloride mediated radical induced asymmetric synthesis of α-methylene bis-g-butyrolactone,
Sumit Saha, Samir Kumar Mandal and Subhas Chandra Roy,
Tetrahedron Lett., 2011, 52, 3128.
12. Titanocene(III) chloride mediated radical induced allylation of aldimines: Formal synthesis of C-linked 4'-deoxy aza-disaccharide,
Sumit Saha, and Subhas Chandra Roy,
J. Org. Chem, 2011, 76, 7229.
13. Titanocene(III) chloride mediated formal synthesis of magnofargesin and 7'-epimagnofargesin,
Pushkin Chakraborty, Samaresh Jana, Sumit Saha and Subhas Chandra Roy,
Tetrahedron lett., 2012, 53, 6584 .
14. Titanocene (III) Chloride Mediated Stereoselective Synthesis of Tri-substituted Tetrahydrofurans and Spirolactone via Tandem Radical Reactions,
Shirshendu Mukherjee, Rajdip Roy, and Subhas Chandra Roy,
Eur. J. Org. Chem., 2014, 64, 2980.
15. Titanocene(III) chloride mediated radical-induced opening of epoxy acetates for the synthesis of primary allylic alcohols: A virtual [1,3] hydroxyl shift,
Pushkin Chakraborty, Samir Kumar Mandal, and Subhas Chandra Roy,
Ind. J. Chem., 2015, 54B, 893.
   
Last Update on July 28, 2015